Hiki i kahi biomarker koko hou ke kōkua i ka wānana i ka pilikia o Alzheimer?

Ke hōʻike nei kahi noiʻi hou he mea nui nā astrocytes, kahi ʻano o ka lolo, no ka hoʻopili ʻana i ka amyloid-β me nā pae mua o ka pathology tau.Karyna Bartashevich/Stocksy

• Hiki i nā astrocytes reactive, kahi ʻano o ka lolo, ke kōkua i ka poʻe ʻepekema e hoʻomaopopo i ke kumu e hoʻomohala ʻole ai kekahi poʻe me ka cognition olakino a me nā waihona amyloid-β i loko o ko lākou lolo i nā hōʻailona ʻē aʻe o Alzheimer, e like me nā protein tau.
• Ua nānā ʻia kahi noiʻi me ka 1,000 mau mea komo i nā biomarkers a ʻike ʻia ua pili wale ʻia ka amyloid-β i nā pae kiʻekiʻe o ka tau i nā poʻe i loaʻa nā hōʻailona o ka astrocyte reactivity.
• Hōʻike nā ʻike he mea nui nā astrocytes no ka hoʻopili ʻana i ka amyloid-β me nā pae mua o ka pathology tau, hiki ke hoʻololi i ke ʻano o kā mākou wehewehe ʻana i ka maʻi o Alzheimer.

ʻO ka hōʻiliʻili ʻana o nā pā amyloid a me nā protein tau i hoʻopaʻa ʻia i loko o ka lolo i manaʻo ʻia ʻo ke kumu nuiʻO ka maʻi o Alzheimer (AD).

ʻO ka hoʻomohala ʻana i ka lāʻau lapaʻau i manaʻo nui i ka huli ʻana i ka amyloid a me ka tau, me ka mālama ʻole i ka hana kūpono o nā kaʻina lolo ʻē aʻe, e like me ka ʻōnaehana neuroimmune.

I kēia manawa, ʻo ka noiʻi hou mai ke Kulanui o Pittsburgh School of Medicine e hōʻike ana he hana koʻikoʻi nā astrocytes, ʻo ia hoʻi nā ʻano lolo o ka hōkū, i ka hoʻoholo ʻana i ka holomua o Alzheimer.

ʻO Astrocytes Pūnaewele Ponoua nui i loko o ka lolo.Ma ka ʻaoʻao o nā cell glial ʻē aʻe, nā cell immune noho o ka lolo, kākoʻo nā astrocytes i nā neurons ma ka hāʻawi ʻana iā lākou i nā meaʻai, oxygen, a me ka pale ʻana i nā pathogens.

Ma mua, ua nānā ʻole ʻia ke kuleana o nā astrocytes i ke kamaʻilio neuronal no ka mea ʻaʻole e alakaʻi nā glial cell i ka uila e like me nā neurons.Akā ʻo ke aʻo ʻana o ke Kulanui o Pittsburg e hoʻohālikelike i kēia manaʻo a hoʻomālamalama i ka hana koʻikoʻi o nā astrocytes i ka olakino lolo a me ka maʻi.

Ua paʻi hou ʻia nā ʻike maNature MedicineTrusted Source.

ʻO ka noiʻi mua e hōʻike ana i ka hoʻopau ʻana i nā kaʻina lolo ma mua o ke kaumaha amyloid, e like me ka hoʻonui ʻana i ka lolo o ka lolo, hiki ke hana koʻikoʻi i ka hoʻomaka ʻana i ke kaʻina pathological o ka make neuronal e alakaʻi ai i ka emi ʻana o ka cognitive wikiwiki o Alzheimer.

Ma kēia noiʻi hou, ua hana nā mea noiʻi i nā hoʻāʻo koko ma luna o 1,000 mau mea komo mai ʻekolu mau haʻawina ʻokoʻa e pili ana i nā poʻe ʻelemakule olakino olakino me ka ʻole o ka amyloid buildup.

Hoʻopili lākou i nā laʻana koko e loiloi i nā biomarkers o ka astrocyte reactivity, ʻo ia hoʻi ka glial fibrillary acidic protein (GFAP), i hui pū ʻia me ke alo o ka pathological tau.

Ua ʻike nā mea noiʻi ʻo ka poʻe wale nō i loaʻa nā ukana amyloid a me nā hōʻailona koko e hōʻike ana i ka hoʻoulu ʻana o ka astrocyte a i ʻole ka reactivity paha e hoʻomohala i ka maʻi Alzheimer i ka wā e hiki mai ana.